Protease Inhibitors and Phosphatase Inhibitors
Cayman Chemical mP-9mP-13 InhIbItr I 1mg
A cell-permeable inhibitor of MMPs that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both); less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively)
Cayman Chemical Src KInase InhIbItr I 1mg
A potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes; also inhibits RIP-2
Cayman Chemical JAK2 InhIbItr V 10mg
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM; blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F
Cayman Chemical GlutamInase C InhIbItr 11 5mg
An inhibitor of GAC; inhibits GAC enzyme activity (EC50 = 10.64 nM); reduces the viability of A549 NSCLC cells (IC50 = 4.025 nM); reduces colony formation by, and intracellular glutamate levels in, A549 cells at 0.1 and 1 µM; reduces tumor growth in an A549 mouse xenograft model at 100 mg/kg
Cayman Chemical Mpro InhIbItr 11b 1mg
An inhibitor of Mpro (IC50 = 0.04 µM in a TR-FRET assay); reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50 = 0.72 µM); reduces viral RNA copy numbers in the same model from 1.85-50 µM
Apexbio Technology LLC PD-1/PD-L1 inhibitor 1(Synonyms: BMS-202, PD-1/PD-L1 interaction inhibitor 1, PD-L1 inhibitor BMS-202, BMS202), 5mg, CAS: 1675201-83-8.
PD-1/PD-L1 inhibitor 1 (CAS 1675201-83-8) is a small molecule inhibitor targeting the interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1 By disrupting PD-1/PD-L1 signaling this agent restores and enhances T-cell activation demonstrating immunomodulatory properties In vitro assays (HTRF binding assay) report IC50 values ranging from 6 to 100 nM Current preclinical evidence positions PD-1/PD-L1 inhibitor 1 as a candidate compound for studying tumor immunity and infectious diseases such as hepatitis C virus infection
Medchemexpress LLC P38 MAP Kinase Inhibitor III | 581098-48-8 | 98.8% | 404.50 | 1 MG
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an IC50 of 0.9 μM. It also inhibits IL-1β and TNF-α release with IC50 values of 0.37 μM and 0.044 μM, respectively.
- Purity: 98.77%
- Appearance: Solid
- Color: White to off-white
Cayman Chemical ALK5 InhIbItr IIhydrochlor 1mg
A selective inhibitor of the TGF-β type 1 receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription
Medchemexpress LLC Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) | 86925-97-5 | 98.8% | 296.36 | 10 MG
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor with a Ki value of 15 nM, and it has an anti-amnesic effect. It strongly inhibits mammalian prolyl endopeptidase in the nM range, and the microbial enzyme with a Ki value of 3.2 μM for Flavobacterium.
- Potent prolyl endopeptidase (PEP; PE) inhibitor.
- Ki value of 15 nM for prolyl endopeptidase.
- Has anti-amnesic effect.
- Inhibits mammalian prolyl endopeptidase with nM order Ki.
- Inhibits microbial enzyme (Flavobacterium) with a Ki value of 3.2 μM.
- Appearance: Solid, white to off-white.
Cayman Chemical SGK1 InhIbItr 1mg
An inhibitor of SGK1 and SGK2 (IC50s = 4.8 and 2.8 nM, respectively); selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP (IC50s = 0.442, 0.924, and 23.3 μM, respectively); only inhibits AMPK by more than 50% in a panel of 60 additional kinases at 1 μM; prevents phosphorylation of GSK3β in U2OS cells (IC50 = 1.4 μM); decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with BYL719; reduces tumor growth in an HCC1954 mouse xenograft model when administered at 50 mg/kg in combination with BYL719
Apexbio Technology LLC MG-132 133407-82-6 25mg
MG-132 (CAS 133407-82-6) is a peptide aldehyde that acts as a proteasome inhibitor It targets the proteolytic activity of the ubiquitin-proteasome system triggering intracellular accumulation of proteins subsequent reactive oxygen species (ROS) production glutathione depletion mitochondrial dysfunction and cytochrome c release leading to apoptosis In vitro studies show MG-132 inhibits growth in various cancer cell lines including A549 lung carcinoma (IC50 20 M) and HeLa cervical cancer (IC50 5 M) through cell-cycle arrest predominantly at G1 and G2/M phases Thus MG-132 is commonly utilized in apoptosis research and cell-cycle regulation studies
Santa Cruz Biotechnology Pladienolide B, 445493-23-2, MFCD22572773, 0.5 mg
Molecular Weight: 536.70, Molecular Formula: C30H48O8, Store at -20° C, BP: ~673.8° C at 760 mmHg, Synonym: Pla-B; (4R,7R,8S,9E,11S,12S)-8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-oxacyclododec-9-en-2-one.
